Synthesis Of Biologycally Active Compounds:

• 1-Sorouri, F., Hosseini, P., Sharifzadeh, M., Kiani, S., Khoobi, M., 2023, In Situ Cross-Linkable Hyaluronic-Ferulic Acid Conjugate Containing Bucladesine Nanoparticles Promotes Neural Regeneration after Spinal Cord Injury, ACS Appl. Mater. Interfaces, https://doi.org/10.1021/acsami.3c08366.

• 2-Abazari, M., Akbari, T., Hasani, M., …Firoozpour, L., Khoobi, M., 2022, Polysaccharide-based hydrogels containing herbal extracts for wound healing applications, Carbohydr. Polym., 294, 119808. [view Image…]

• 3-
  Pourabdi, L., Küçükkılınç, T.T., Khoshtale, F., Ayazgök, B., Nadri, H., Farokhi Alashti, F., Forootanfar, H., Akbari, T., Shafiei, M., Foroumadi, A., Sharifzadeh, M., Shafiee Ardestani, M., Abaee, M.S., Firoozpour, L., Khoobi, M., Mojtahedi, M.M., 2022, Synthesis of New 3-Arylcoumarins Bearing N-Benzyl Triazole Moiety: Dual Lipoxygenase and Butyrylcholinesterase Inhibitors With Anti-Amyloid Aggregation and Neuroprotective Properties Against Alzheimer’s Disease. Front Chem. 9, 810233.

• 4-
  Sorouri, F., Emamgholipour, Z., Keykhaee, M., Najafi, A., Firoozpour, L., Sabzevari, O., Sharifzadeh, M., Foroumadi, A., Khoobi, M., 2022, The situation of small molecules targeting key proteins to combat SARS-CoV-2: Synthesis, metabolic pathway, mechanism of action, and potential therapeutic applications. Mini Rev Med Chem. 22(2), 273–311.
  

• 5-
  Abdpour, Sh., Jalili-Baleh, L., Nadri, H., Forootanfar, H., Abbas Bukhari, S.N., Ramazani, A., Sadat Ebrahimi, S.E., Foroumadi, A., Khoobi, M., 2021,Chromone Derivatives Bearing Pyridinium Moiety as Multi-Target-Directed Ligands against Alzheimer’s disease. Bioorganic Chemistry, 104750.
• 6-
  Sadeghi, A., Saedisomeolia, A., Jalili-Baleh, L., Khoobi, M., Soleimani, M., Fakhr Yasseri, A.M., Yekaninejad, M.S., Farzin, A., Amini, E., Nowroozi, M.R., 2022, FruHis significantly increases the anti-benign prostatic hyperplasia effect of lycopene: A double-blinded randomized controlled clinical trial. Front Nutr., 9,1011836.

• 7-
  Yadavar-Nikravesh, M-S., Ahmadi, S., Milani, A., Akbarzadeh, I., Khoobi, M., Vahabpour, R., Bolhassani, A., Bakhshandeh, H., 2021, Construction and characterization of a novel Tenofovir-loaded PEGylated niosome conjugated with TAT peptide for evaluation of its cytotoxicity and anti-HIV effects, Adv Powder Technol, 32 (9), 3161-3173.
• 8-
  Barzegarzadeh, B., Hatami, H., Dehghan, G., Khajehnasiri, N., Khoobi M., Sadeghian R., 2021, Conjugated Linoleic Acid-Curcumin Attenuates Cognitive Deficits and Oxidative Stress Parameters in the Ethidium Bromide-Induced Model of Demyelination. Neurotox Res. 39 (3):815-825.
• 9-

  Abdpour, Sh., Jalili-Baleh, L., Nadri, H., Forootanfar, H., Abbas Bukhari, S.N., Ramazani, A., Sadat Ebrahimi, S.E., Foroumadi, A., Khoobi, M., 2021,Chromone Derivatives Bearing Pyridinium Moiety as Multi-Target-Directed Ligands against Alzheimer’s disease. Bioorganic Chemistry, 104750.
  [view Image…]
  
  
  

• 10-

  Hamidinasab, M., Ameri, A., Hekmat, A., Forootanfar, H., Mortezazadeh, T., Bodaghifard, M.A., Peytam, F., Esmaeili, R., Foroumadi, A., Sharifzadeh, M., Mobinikhaledi, A., Khoobi, M., 2021, Mono-and bis-pyrazolophthalazines: Design, synthesis, cytotoxic activity, DNA/HSA binding and molecular docking studies. Bioorganic & Medicinal Chemistry, 30, 115944.
  [view Image…]
  
  
  

• 11-

  Salehian, F., Nadri, H., Jalili-Baleh, L., Youseftabar-Miri, L., Bukhari, S.N.A., Foroumadi, A., Tüylü Küçükkilinç, T., Sharifzadeh, M., Khoobi, M., 2020. A Review: Biologically active 3, 4-heterocycle-fused coumarins. European Journal of Medicinal Chemistry, DOI: 10.1016/j.ejmech.2020.113034
  [view Image…]
  
  
  

• 12-

  Jalili-Baleh, L.; Babaei, E.; … Khoobi, M., 2018, A review on flavonoid-based scaffolds as multi-target-directed ligands (MTDLs) for Alzheimer’s disease, European Journal of Medicinal Chemistry, 152, 570-589.
  [view Image…]
  
  
  

• 13-

  Jalili-Baleh, L.; Forootanfar, H.; Tüylü Küçükkılınç, T.; … Khoobi, M., 2018, Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimer’s disease based on coumarin and lipoic acid scaffolds. European Journal of Medicinal Chemistry, 152, 600-614.
  [view Image…]
  
  
  

• 14-

  Gholibegloo, E., Karbasi, A., Pourhajibagher, M., Chiniforush, N., Ramazani, A., Akbari, T., Bahador, A., Khoobi, M., 2018, Carnosine-graphene oxide conjugates decorated with hydroxyapatite as promising nanocarrier for ICG loading with enhanced antibacterial effects in photodynamic therapy against Streptococcus mutans, Journal of Photochemistry and Photobiology B:Biology, 181, 14-22.
  [view Image…]
  
  
  

• 15-

  Jalili-Baleh, L.; Nadri, H.; Moradi, A.; Shakibaie, M.;…, Khoobi, M., 2017, New racemic annulated pyrazolo[1,2-b]phthalazines as tacrine-like AChE inhibitors with potential use in Alzheimer’s disease, European Journal of Medicinal Chemistry, 139,280-289.
  [view Image…]
  
  
  

• 16-

  Akrami, H.; Safavi, M.;… Khoobi, M., 2017, Facile synthesis and antiproliferative activity of 7H-benzo[7,8]chromeno[2,3-d]pyrimidin-8-amines, European Journal of Medicinal Chemistry 127, 128-136.
  [view Image…]
  
  
  

• 17-

  Golshani, M; Khoobi, M.; et al., 2017, A transition-metal-free fast track to flavones and 3-arylcoumarins, Chemical Communication, 53, 10676-10679.
  [view Image…]
  
  

• 18-

  Ghanei-Nasab, S.; Khoobi, M.; Hadizadeh, F.; … 2016, Synthesis and anticholinesterase activity of coumarin-3-carboxamides bearing tryptamine moiety, European journal of medicinal chemistry, 121, 40-46.
  [view Image…]
  
  
  

• 19-

  Pourabdi, L.; Khoobi, M.; Nadri, H; 2016, Synthesis and structure-activity relationship study of tacrine-based pyrano[2,3-c]pyrazoles targeting AChE/BuChE and 15-LOX. European journal of medicinal chemistry, 123, 298-308.
  [view Image…]
  
  
  

• 20-

  Khoobi, M.; Molaverdi, F.; Jafarpour, F.; Abbasnia, M.; Kubicki, M.; Shafiee, A.; 2015, A One-Pot Domino C-H, C-C Activation in Coumarins: Fast Track to 2,3-diaryl benzo[b]furans, Chemical Communication, 51, 11713-11716.
  [view Image…]
  
  
  

• 21-

  Shafii, N.; Khoobi, M.;Amini, M.; Sakhteman, A.; Nadri, H.; Moradi, A.; Emami. S.; Saeedian Moghadam, A.; Foroumadi, A.; Shafiee, A. 2015, Synthesis and biological evaluation of 5-benzylidenerhodanine-3-acetic acid derivatives as AChE and 15-LOX inhibitors, Journal of Enzyme Inhibition and Medicinal Chemistry, 30 (3), 389-395.
  [view Image…]
  
  
  

• 22-

  Khoobi, M.; Ghanoni, F.; Nadri, H.; Moradi, A.; Pirali Hamedani, M.; Homayouni Moghadam, F.; Emami, S.; Vosooghi, M.; Zadmard, R.; Foroumadi, A.; Shafiee, A. 2014,New tetracyclic tacrine analogs containing pyrano[2,3-c]pyrazole: Efficient synthesis, biological assessment and docking simulation study. European Journal of Medicinal Chemistry, 89, 296-303.
  [view Image…]
  
  
  

• 23-

  Heidary, M.; Khoobi, M.; Ghasemi, S.; Habibi, Z.; Faramarzi, M.A. 2014, Synthesis of Quinazolinones from Alcohols via Laccase-Mediated Tandem Oxidation. Advanced Synthesis & Catalysis, 356, 1789–1794.
  [view Image…]
  
  
  

• 24-

  Alipour, M.; Khoobi, M.; Moradi, M.; Nadri, M.; Homayouni Moghadam, F.; Emami, S.; Hasanpour, Z.; Foroumadi, A.; Shafiee, A. 2014, Synthesis and anti-cholinesterase activity of new 7-hydroxycoumarin derivatives. European Journal of Medicinal Chemistry, 82, 536-544.
  [view Image…]
  
  
  

• 25-

  Ramazani, A.; Khoobi, M.; Torkaman, A.; Zeinali Nasrabadi, F.; Forootanfar, H.; Shakibaie, M.; Jafari, M.; Ameri, A.; Emami, S.; Faramarzi, M. A.; Foroumadi, A.; Shafiee, A. 2014, One-pot, four-component synthesis of novel cytotoxic agents 1-(5-aryl-1,3,4-oxadiazol-2-yl)-1-(1H-pyrrol-2-yl)methanamines, European Journal of Medicinal Chemistry, 78, 151-156.
  [view Image…]
  
  
  

• 26-

  Akrami, H.; Mirjalili, B. F.; Khoobi, M.; Nadri, H; Moradi, A.; Sakhteman, A.; Emami, S.; Foroumadi, A; Shafiee, A. 2014, Indolinone-based acetylcholinesterase inhibitors: synthesis, biological activity and molecular modeling, European Journal of Medicinal Chemistry, 84, 375-381.
  [view Image…]
  
  
  

• 27-

  Jafarpour, F., Hazrati, H., Mohasselyazdi, N., Khoobi, M., Shafiee, A., 2013, Palladium catalyzed dehydrogenative arylation of coumarins: an unexpected switch in regioselectivity, Chemical Communication, 49, 10935-10937.
  [view Image…]
  
  
  

• 28-

  Asadipour, A., Alipour, M., Jafari, M., Khoobi, M., Emami, S., Nadri, H., Sakhteman, A., Moradi, A., Sheibani, V., Moghadam, F. H., Shafiee, A., Foroumadi, A., 2013, Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors. European Journal of Medicinal Chemistry, 70, 623-630.
  [view Image…]
  
  
  

• 29-

  Khoobi, M., Alipour, M., Moradi, A., Sakhteman, A., Nadri, H., Razavi, S. F., Ghandi, M., Foroumadi, A., Shafiee, A., 2013, Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3′,4′:5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase. European Journal of Medicinal Chemistry, 68, 291-300.
  [view Image…]
  
  
  

• 30-

  Khoobi, M., Alipour, M., Sakhteman, A., Nadri, H., Moradi, A., Ghandi, M., Emami, S.,Foroumadi, A., Shafiee, A., 2013, Design, synthesis, biological evaluation and docking study of 5-oxo-4,5-dihydropyrano[3,2-c]chromene derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors. European Journal of Medicinal Chemistry, 68, 260-269.
  [view Image…]